Methods	Randomisation: manufacturer provided envelopes containing numbers corresponding to boxes of capsules, for each enrolled participant a random envelope was opened Allocation concealment: Done Participants masked: No (‘you can taste the fish oil’) Providers masked: Unclear Outcome assessors masked: yes Summary risk of bias: medium or high
Participants	N: 15 low dose, 15 medium dose, 14 high dose, 14 control Level of risk for CVD: Low (healthy monks) Male: 100% Mean age, sd: overall: 56.2, 16.5 Age range: Unclear Smokers: Unclear Hypertension: None Location: The Netherlands
Interventions	Type: supplement (capsule) Intervention: Fish oil capsules, all took 9 per day, double dummy, some with Olive and palm oil capsules (1.1g omega-3 fats low dose, 2.2g medium dose, 3.3g high dose per day) Control: 9 Olive and palm oil capsules (0g omega-3 fats per day) Compliance: ‘excellent’ in all groups according to capsule count, plasma cholesteryl esters rose from 0.8 to 3.8 low intake, 0.9 to 6.6 medium intake, 0.7 to 10.4 high intake and 0.9 to 0.9 control group from 0 to 12 mo. Length of intervention: 12 mo
Outcomes	Main study outcome: tissue incorporation Dropouts: none? Available outcomes: deaths, lipids, blood pressure Response to contact: yes
Notes	Dietary assessment suggested that total diet plus supplement intakes were as follows 1.5g/d EPA + DHA + DPA low intake, 2.5g/d medium intake, 3.6g/d high intake, 0.4g/d control group
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Yes	A - Adequate