Skip to main content
. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007113. doi: 10.1002/14651858.CD007113.pub2
Methods Randomised controlled trial, pilot study recruiting alongside another larger trial
Participants 167 women with singleton pregnancies 24 to 36 weeks; outpatients; previous normal anatomy scan; ultrasound showing abdominal circumference < 10th percentile, 2 measures of umbilical artery Doppler resistive index < 95th centile, no oligohydramnios
Interventions Twice-weekly versus fortnightly fetal surveillance. Surveillance methods include biophysical profile, nonstress tests, umbilical artery and middle cerebral artery Doppler, growth scans and uterine artery Doppler
Outcomes Neonatal; gestational age at delivery, umbilical artery resistive index at delivery, abnormal umbilical artery at delivery, female sex, birthweight, birthweight < 10th percentile, ponderal index, ponderal index < 10th percentile, admission to neonatal nursery, neonatal hospital stay, acidosis at birth, hypogylcemia
Maternal: spontaneous onset of labour, induction of labour, caesarean delivery, caesarean delivery for fetal distress, pre-eclampsia, gestational hypertension
Notes Sample size calculated for main study, no prespecified single primary outcome for this pilot complementary study
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Yes Computer-generated numbers.
Allocation concealment? Yes Central telephone randomisation service.
Blinding?
All outcomes
Unclear Not feasible to blind participant and unclear if clinician or outcome assessors were blinded
Incomplete outcome data addressed?
All outcomes
Yes No loss to follow up documented.