1 Quality of life ‐ SGRQ (change scores) |
4 |
3442 |
SGRQ (Random, 95% CI) |
‐2.69 [‐3.82, ‐1.55] |
2 Quality of life ‐ SGRQ (change scores) |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
3 Change from baseline in St George's Respiratory Questionnaire (domain ‐ symptoms) |
2 |
2233 |
Mean Difference (IV, Random, 95% CI) |
‐3.43 [‐5.13, ‐1.72] |
4 Change from baseline in St George's Respiratory Questionnaire (domain ‐ activity) |
2 |
2215 |
Mean Difference (IV, Random, 95% CI) |
‐1.57 [‐2.87, ‐0.27] |
5 Change from baseline in St George's Respiratory Questionnaire (domain ‐ impact) |
2 |
2222 |
Mean Difference (IV, Random, 95% CI) |
‐2.28 [‐3.60, ‐0.95] |
6 Mean FEV1 (% increase from baseline) |
1 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Totals not selected |
7 Mean change from baseline in pre dose FEV1 to the average over the randomised treatment period. |
2 |
1203 |
Mean Difference (IV, Random, 95% CI) |
0.05 [0.00, 0.09] |
8 Symptoms ‐ breathlessness (change scores) |
2 |
2308 |
Mean Difference (IV, Random, 95% CI) |
‐0.07 [‐0.12, ‐0.01] |
9 Change from baseline in cough score |
2 |
2308 |
Mean Difference (IV, Random, 95% CI) |
‐0.06 [‐0.11, ‐0.00] |
10 Change from baseline in rescue medication usage (puffs/day) |
2 |
2310 |
Mean Difference (IV, Random, 95% CI) |
‐0.33 [‐0.57, ‐0.09] |
11 Adverse events ‐ 'serious' events |
4 |
3243 |
Odds Ratio (M‐H, Random, 95% CI) |
0.92 [0.69, 1.25] |
12 Adverse events ‐ candidiasis |
2 |
|
Odds Ratio (M‐H, Random, 95% CI) |
Subtotals only |
13 Withdrawals due to adverse events |
4 |
3243 |
Odds Ratio (M‐H, Random, 95% CI) |
0.88 [0.65, 1.19] |
14 Withdrawals due to worsening COPD symptoms |
2 |
918 |
Odds Ratio (M‐H, Random, 95% CI) |
0.49 [0.32, 0.74] |