Methods	RCT
Participants	200 women with CIN undergoing knife cone biopsy
Interventions	Lateral haemostatic sutures and interrupted sutures if indicated Vaginal pack with Monsels solution
Outcomes	Duration of surgical procedure Operative blood loss Primary haemorrhage Secondary haemorrhage
Notes
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Details about the sequence generation was not given, “Patients were randomly allocated to one or the other haemostatic method by opening one of a batch of sealed envelopes containing the appropriate instruction”
Allocation concealment?	Yes	“We performed the method allocation after the cone excision to ensure that previous knowledge of the haemostatic method could not influence the operator as to the size or shape of the cone”
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	For all outcomes: % analysed: 200/205 (98%) 5 women did not wish to participate
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists