Methods	RCT
Participants	125 women with CIN 1,2,3 Women with satisfactory colposcopy, negative endocervical curettage, reproductive years
Interventions	Laser ablation Cryotherapy
Outcomes	Vasovagal reaction Patient acceptance (would patient have repeat treatment) Satisfactory colposcopy at 4 months Residual disease at 4 and 12 months
Notes	42 women were randomised to laser ablation, 39 to cryotherapy and completed protocol Laser performed ablated 2 mm lateral to transformation zone to a depth of 5-7mm. Women had pre-operative oral ibuprofen Cryocoagulation (double freeze thaw freeze technique) or more if the ice ball did not exceed the probe (28mm) by 4-5mm. With or without analgesia
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	No	% of women analysed: 81/125 (65%) “Characteristics of those patients lost from the study were similar in both … arms”
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists