Methods	RCT
Participants	106 women with CIN 3 Adequate colposcopy and no extension to vagina
Interventions	Laser ablation Cryotherapy
Outcomes	Residual disease at 4 and 10 months
Notes	71 women were randomised to laser ablation, 35 to cryotherapy Laser performed ablated transformation zone to a depth of 7mm Cryocoagulation (double freeze thaw freeze technique)
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 106/106 (100%)
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists