Methods	RCT
Participants	183 women with CIN 2 or 3
Interventions	Knife cone with anterior+posterior Sturmdorf sutures Knife cone without haemostatic sutures but with vaginal packing for 6-8 hours Laser cone
Outcomes	Resection margins free of disease Primary haemorrhage Secondary haemorrhage Cervical stenosis Dysmenorrhoea
Notes	62 women randomised to knife cone with sutures, 60 women to knife cone with packing, 61 to laser cone All procedures performed under general anaesthesia All procedures performed with lateral sutures and intracervical vasopressin
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 163/183 (89%) for cervical stenosis at follow up By treatment arms Laser: 56/61 (92%) Knife: 107/122 (88%) All other outcomes have follow up greater than 89%
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists