Methods	RCT
Participants	105 women with CIN 1,2,3 Adquate colposcopy, no suspicion of invasion
Interventions	Laser ablation Cryotherapy
Outcomes	Peri-operative pain Peri-operative bleeding Residual disease at 3-18 months
Notes	Laser performed ablating the transformation zone to a depth of 6-7mm Cryocoagulation (double freeze thaw freeze technique) using a probe (18mm) 2 women in cryotherapy group, 2 women in laser group lost to follow up
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 101/105 (96%) “One patient in the cryotherapy group was lost to follow up … an additional patient treated with cryotherapy and two treated with laser … are excluded”
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists