Methods	RCT
Participants	110 women with CIN 3
Interventions	Laser conisation Knife conisation
Outcomes	Peri-operative blood loss (insufficient data for analysis) Primary haemorrhage (bleeding requiring intervention in first 4 days) Secondary haemorrhage (bleeding after 4th day)
Notes	55 women were randomised to laser conisation, 55 to knife conisation All procedures performed under general anaesthesia Blood loss estimated by alkaline haematin extraction from swabs etc
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 110/110 (100%)
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists