Methods	RCT
Participants	110 women with CIN 1,2,3 Squamo-columnar junction not completely visible
Interventions	Knife cone Laser cone LLETZ
Outcomes	Ectocervical resection margin involved with disease Endocervical resection margin involved with disease Presence of thermal artifact not permitting evaluation of resection margins Peri-operative bleeding requiring haemostatic sutures (loop+laser only) Secondary haemorrhage Cervical stenosis Satisfactory colposcopy Residual disease at 6 months Residual disease at 36 months
Notes	37 women were randomised to knife conisation, 37 to laser conisation, 36 to loop All 3 treatments performed as an out-patient procedure with 10-20 mls 1% xylocaine with ephedrine. At knife conisation haemostasis was achieved by Sturmdorf sutures, laser cone by laser coagulation and Monsels solution, loop excision by coagulation and Monsels solution In 2004 update 86 patients were followed up for more than 3 years. Of these 28 had been treated with the cold knife, 29 with LEEP and 29 by laser
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“Allocation was accomplished by drawing envelopes containing the names of the procedures (distribution of the different procedures was done according to a hazard table)”
Allocation concealment?	Unclear	It was not reported whether or not sealed, opaque envelopes were used
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 110/110 (100%)
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists