Methods	RCT
Participants	498 women with CIN 1,2,3 Women over 18 yrs, using contraception, biopsy proven CIN, satisfactory colposcopy with lesion entirely visible Age details in the trial were as follows: <25 years: 171 (44%), 25-29: 105 (27%), >29: 114 (29%) There were 123 (32%) women with CIN 1, 124 (32%) with CIN 2 and 143 (36%) with CIN 3
Interventions	Cryotherapy Laser ablation Loop Excision
Outcomes	Residual disease Primary haemorrhage Secondary haemorrhage
Notes	139 women were randomised to cryotherapy, 121 to laser ablation, 130 to loop excision
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“A physician assistant who was not involved in treatment used the computer generated list to assign the random treatment and scheduled the patient”
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	No	% of women analysed: 390/498 (78%) No breakdown of numbers in treatment arms
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists