Methods	RCT
Participants	447 women with CIN 1,2,3 Women with suspicion of invasion, extensive lesion, pregnant were excluded 153 patients (24%) were candidates for other type of treatment due to conditions contraindicating 1-day management
Interventions	LLETZ Laser conisation
Outcomes	Residual disease Significant peri-operative bleeding Secondary haemorrhage Cervical stenosis at follow up Satisfactory colposcopy at follow up
Notes	145 women randomised to laser conisation, 147 to loop Intracervical 6mls 2% lidocaine with 1:80,000 ephedrine used pre-operatively
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“A list was elaborated using an aleatory numbers’ table, and according to that order new patients were correlatively allocated at each therapeutic arm”
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 294/294 (100%)
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists