Methods	RCT
Participants	142 women with ectocervical CIN 1 and 2
Interventions	Single freeze Double freeze Cryotherapy
Outcomes	Residual disease at 6 months
Notes	61 underwent single freeze 81 underwent double freeze
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“By using random numbers the patients were assigned to either single-freeze or double freeze treatment”
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% of women analysed: 142/142 (100%)
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists