Methods	RCT
Participants	123 women with CIN1,2,3
Interventions	Laser conisation Knife conisation
Outcomes	Duration Peri-operative bleeding (quantity mls) Post-operative bleeding (primary requiring treatment and secondary) Post-operative pain (use of analgesics) Adequate colposcopy Cervical stenosis (failure to pass cotton swab) Women complaining of dysmenorrhoea Residual disease (3-36 months)
Notes	All procedures performed under general anaesthesia Knife cone biopsy women had vaginal packing for 24 hours and 3 gms Tranexamic acid for 10 days. Sturmdorf sutures were not used, lateral cervical arteries used Laser conisation women did not have vaginal packing or tranexamic acid 59 women randomised to laser conisation, 64 to knife conisation
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not reported
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	For Inadequate colposcopy and cervical stenosis at follow up outcomes: % analysed: 113/123 (92%) Laser: 56/59 (95%) Knife: 57/64 (89%) All other outcomes had less loss to follow up
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists