Comparison 2.

Laser ablation versus cryotherapy

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Residual Disease (All Grades of CIN)	6	935	Risk Ratio (IV, Random, 95% CI)	1.13 [0.73, 1.76]
2 Residual Disease (CIN1, CIN2, CIN3)	4	567	Risk Ratio (IV, Random, 95% CI)	1.51 [0.91, 2.51]
2.1 CIN1	4	73	Risk Ratio (IV, Random, 95% CI)	2.75 [0.68, 11.11]
2.2 CIN2	4	289	Risk Ratio (IV, Random, 95% CI)	1.37 [0.65, 2.88]
2.3 CIN3	4	205	Risk Ratio (IV, Random, 95% CI)	1.38 [0.62, 3.09]
3 Peri-operative Severe Pain	3	493	Risk Ratio (IV, Random, 95% CI)	2.00 [0.64, 6.27]
4 Peri-operative Severe Bleeding	2	305	Risk Ratio (IV, Random, 95% CI)	5.83 [0.71, 47.96]
5 Vaso-motor Symptoms	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6 Malodorous Discharge	2	400	Risk Ratio (IV, Random, 95% CI)	0.30 [0.12, 0.77]
7 Inadequate Colposcopy at Follow-up	2	272	Risk Ratio (IV, Random, 95% CI)	0.38 [0.26, 0.56]
8 Cervical Stenosis at Follow-up	2	464	Risk Ratio (IV, Random, 95% CI)	1.45 [0.45, 4.73]