Methods | RCT | |
Participants | 289 women with CIN I,II,III | |
Interventions | Laser ablation LLETZ |
|
Outcomes | Residual/recurent disease Primary haemorrhage Duration of pregnancy |
|
Notes | 134 allocated to laser ablation. 120 received allocated treatment 155 allocated to LLETZ 151 received allocated treatment |
|
Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Yes | “Consecutively numbered, sealed, opaque envelopes were used to allocate women to treatment with loop diathermy excision of the transformation zone or laser vaporisation according to a computer generated randomisation schedule stratified by centre” |
Allocation concealment? | Yes | “Consecutively numbered, sealed, opaque envelopes were used” |
Blinding? All outcomes |
Unclear | Not reported |
Incomplete outcome data addressed? All outcomes |
Yes | % of women analysed: 285/289 (99%) |
Free of selective reporting? | Unclear | Insufficient information to permit judgement |
Free of other bias? | Unclear | Insufficient information to assess whether an important risk of bias exists |