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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jun 16;(6):CD001318. doi: 10.1002/14651858.CD001318.pub2
Methods RCT
Participants 289 women with CIN I,II,III
Interventions Laser ablation
LLETZ
Outcomes Residual/recurent disease
Primary haemorrhage
Duration of pregnancy
Notes 134 allocated to laser ablation. 120 received allocated treatment
155 allocated to LLETZ
151 received allocated treatment
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Yes “Consecutively numbered, sealed, opaque envelopes were used to allocate women to treatment with loop diathermy excision of the transformation zone or laser vaporisation according to a computer generated randomisation schedule stratified by centre”
Allocation concealment? Yes “Consecutively numbered, sealed, opaque envelopes were used”
Blinding?
All outcomes
Unclear Not reported
Incomplete outcome data addressed?
All outcomes
Yes % of women analysed: 285/289 (99%)
Free of selective reporting? Unclear Insufficient information to permit judgement
Free of other bias? Unclear Insufficient information to assess whether an important risk of bias exists