Methods	RCT
Participants	180 women recruited with all grades of CIN with the following inclusion criteria: 1) unsatisfactory colposcopy with positive biopsy 2) endocervical curettage with positive biopsy 3) possible microinvasion on biopsy
Interventions	LLETZ Knife conisation
Outcomes	Adequate colposcopy Cervical stenosis Incomplete resection margins Residual disease at 3 months
Notes	91 women randomised to LLETZ 89 women randomised to knife conisation
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“Randomization to receive treatment by cold-knife conization (n = 89) or conization by the loop electrosurgical excision procedure (n = 91) was accomplished with a computer program using a permuted block design”
Allocation concealment?	Unclear	Not reported
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	No	% of women analysed: 140/180 (78%) were assessed for cervical stenosis. All other outcomes assessed more than 140 patients
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists