Methods	RCT
Participants	78 women with CIN 2,3 Mean age in the trial was 35.6 years (SD=8.2 years) There were 18 (27%) women with CIN II and 48 (73%) with CIN 3
Interventions	Knife conisation LLETZ
Outcomes	Residual disease Post-operative bleeding Cervical stenosis Adequate colposcopy
Notes	78 women randomised Only 66 available for follow up: 38 knife cone 28 laser excision
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“Women were assigned to the cold knife or loop excision group using a random-number table”
Allocation concealment?	Yes	“Group allocation predetermined and placed in consecutively numbered sealed envelopes”
Blinding? All outcomes	Unclear	Not reported
Incomplete outcome data addressed? All outcomes	Yes	% analysed: 66/78 (85%) No breakdown given in terms of groups
Free of selective reporting?	Unclear	Insufficient information to permit judgement
Free of other bias?	Unclear	Insufficient information to assess whether an important risk of bias exists