Table 2.
Histopathological and parasitological evaluation of liver in canine visceral leishmaniasis. Analyses of presence quantification (P) and grading (G) of tissues abnormalities following the distribution: slight (S), moderate (M) and severe (SV)
| Symptomatic n = 19 | Asymptomatic n = 11 | Control n = 9 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Grading | aP ≤ 0.05 | Grading | aP ≤ 0.05 | Grading | |||||||
| Histopathology | S | M | SV | G/P | S | M | SV | G/P | S | M | SV |
| Inflammation | 8 | 5 | 3 | */* ** | 5 | 2 | 2 | */* | 0 | 0 | 0 |
| Hypertrophy/hyperplasia of Kupffer | 5 | 10 | 3 | */* | 3 | 6 | 2 | */* | 0 | 0 | 0 |
| Intralobular granulomas | 5 | 3 | 1 | */* ** | 3 | 3 | 2 | */* | 0 | 0 | 0 |
| Degeneration | 5 | 8 | 6 | */* | 2 | 6 | 3 | */* | 2 | 0 | 0 |
| Congestion | 4 | 10 | 2 | */* | 5 | 3 | 3 | */* | 2 | 0 | 0 |
| Haemosiderin | 5 | 3 | 0 | * **/* ** | 2 | 0 | 0 | */* | 0 | 0 | 0 |
| Fibrosis (μm2)b | 2751 ± 866*, ** | 2039 ± 597 | 1567 ± 303 | ||||||||
| Parasitological diagnosisb | 26.4 ± 5** | 10.6 ± 2 | |||||||||
a
Significant differences (P ≤ 0.05) relative to control are represented by * and relative to asymptomatic by **.
b
Values are shown as mean ± standard deviation.