Methods	RCT Single centre. 21 women randomised
Participants	Age: mean 47 years, range 26-63 years VIN grade: 21 high grade Smoking: not documented HPV status: “almost all women”
Interventions	Imiquimod vs placebo for 16 weeks
Outcomes	Response to treatment: 8 weeks and 20 weeks. HPV clearance
Notes	Abstract not full paper
Risk of bias
Bias	Authors’ judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Not reported
Allocation concealment?	Unclear risk	Not reported
Blinding? All outcomes	Unclear risk	Not reported
Incomplete outcome data addressed? All outcomes	Unclear risk	Not reported
Free of selective reporting?	Unclear risk	Unclear
Free of other bias?	Unclear risk	Unclear