Study	Reason for exclusion
Iavazzo 2008	This is a review of the use of imiquimod in high grade VIN and vaginal intraepithelial neoplasia (VAIN). The studies included were either observational cohort studies (case series) or case reports published between 1997 and 2007. The only RCT included in this review was Mathiesen 2007 this trial was already included in our analysis.
Mahto 2010	This was a recent review of the use of imiquimod in anogenital intraepithelial neoplasia, it included studies for VIN, penile and anal intraepithelial neoplasia. Similarly to Iavazzo 2008 it included observational cohort studies (case series) or case reports published between 1997 and 2008 with the addition of a second RCT van Seters 2008 also included in our review.
Mathiesen 2008	This publication was a response to the letter by van de Nieuwenhof 2008 referring to the authors trial (Mathiesen 2007).
Melamed 1965	This was a Russian article describing the condition and was not an RCT. There was no active medical treatment in 1965
Spirtos 1990	This was a cross over trial that did not use a true randomised cross over approach as cross over was conditional on patient response/non-response - lack of a clear time line of treatment for each patient. - the exact duration of treatment in each arm, for the patients that were crossed over was not stated
Todd 2005	Review article looking at various modalities of treatment.
van de Nieuwenhof 2008	Letter to the editor referring to the trial of Mathiesen 2007.