Table 1. Group mean ECG parameters in single-dose cardiovascular safety study in monkeys.

Time Interval	Treatment Day	RR (msec)	PR (msec)	QRS (msec)	QT (msec)	QTc (msec)
Hours 1 – 4	Vehicle	481.37	111.63	38.00	243.13	177.13
	Day 1	513.25*	116.25*	38.38	254.88*	180.25
	Day 3	553.00*	118.38*	38.13	264.75*	171.63
	Day 7	561.00*	119.38*	39.00*	269.00*	172.39
	Day 10	538.00*	116.88*	38.88*	261.25*	174.63
	Day 14	550.50*	118.00*	39.00*	264.87*	171.75
Hours 5 – 7	Vehicle	502.38	119.62	39.50	249.38	174.38
	Day 1	511.25	121.12	38.88	251.63	177.25
	Day 3	514.25	118.62	38.75	254.13	174.13
	Day 7	513.25	117.87	39.50	253.75	174.36
	Day 10	498.38	117.25	39.00	251.38	180.38
	Day 14	513.25	119.75	39.13	253.88	175.12
Hours 7 – 18	Vehicle	602.25	120.00	39.63	299.38	185.25
	Day 1	624.38	122.50*	39.38	310.00	193.25
	Day 3	631.50*	119.88	39.25	306.38	180.13
	Day 7	663.75*	121.38	39.88	312.50*	177.07
	Day 10	602.38	120.38	39.63	299.88	190.00
	Day 14	659.38*	123.87*	39.75	314.00*	179.87
Hours 18 – 22	Vehicle	541.37	115.50	38.88	273.38	183.50
	Day 1	598.25*	119.25*	39.00	294.25*	188.13
	Day 3	604.62*	117.00	39.00	295.38*	178.75
	Day 7	646.25*	119.62*	39.13	305.88*	178.25
	Day 10	597.37*	119.50*	39.25	296.00*	188.25
	Day 14	644.25*	120.62*	39.25	307.88*	179.63

^*P < 0.05 compared with vehicle treatment