Figure 3. The HER2-F0178C1 Fab complex structure and interface. A, ribbon diagrams representations of the F0178C1Fab (left) and the HER2- F0178C1 Fab complex (right) and surface corresponding to the ribbon diagrams shown above with the same color scheme. The light chain and heavy chains of the F0178C1 Fab are colored pink and wheat, respectively, whereas HER2 molecules are colored as Figure 2. Contact surfaces are highlighted in blue on F0178C1 and red on HER2. B, stereo view of the detailed HER2- F0178C1 Fab interface. The residues that are involved in the intermolecular interaction are shown as colored sticks with the same scheme as the surface representation above; the F0178C1 Fab and HER2 molecules are presented as ribbon diagrams. Dashed lines denote hydrogen bonds.