Figure 5. The F0178C1 epitope may overlap with the HER2-ligand interaction interface. (A) Effects of key residues on the antibody-HER2 interface on HER2 dimerization. (B) Locations of the key residues represents on the right. (C) Fluorescence-activated cell sorting analysis with the 20 ug of FITC labeled antibody pertuzumab. (D) Comparison the relative location of different anti-domain III antibodies. Domains I, II, III, and IV of the ErbB2 ECD protomer are colored as Figure 2. Antibody F0178C1 is colored wheat and Fab37 is colored bluewhite and modeled use PDB ID 3N85, cetuximab is colored yellow and modeled using PDB ID 1YY