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. 2014 Apr 16;6(4):978–990. doi: 10.4161/mabs.28786

Table 2. Pharmacokinetic parameters of recombinant anti-ErbB2 antibodies in mice.

        Trastuzumab-biotin-based competitive ELISA       Pertuzumab-biotin-based competitive ELISA
      Parametera       Trastuzumab       F0178       F0179       Pertuzumab       F0178       F0179
      AUC (day μg ml−1)       419.91       399.23       389.12       312.56       321.67       331.87
      T1/2(day)       6.12       6.14       6.57       7.11       6.89       6.37
      CL (ml day−1 kg−1)       11.15       10.91       11.50       10.11       9.89       10.04
      VSS(ml kg−1)       55.78       56.89       59.33       50.14       48.15       51.44

a Pharmacokinetic parameters were calculated using a noncompartmental analysis. AUC, area under the concentration vs. time curve; t1/2, half-life; CL, clearance; VSS, steady-state volume of distribution.