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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Sep 8;(9):CD008148. doi: 10.1002/14651858.CD008148.pub2
Methods Randomized blinded, placebo-controlled clinical trial (little information about study methods)
Participants 26 women with gestational age between 27-37 weeks diagnosed with HELLP syndrome (criteria for diagnosis not clear).
Exclusions: women with chorioamnionitis.
Interventions Intervention group: (13) 10 mg dexamethasone IV every 12 hrs (2 doses) then 5 mg every 12 hrs (2 doses), total dose of 30 mg over 36 hours
Control group: (13) no corticosteroid.
All women were given a 6 g dose of magnesium sulfate (approximately 1.5 g/hr). All women gave birth within 12 hours
Outcomes MAP, urinary output, serum glutanic aspartate aminotransferase (AST), alamine aminotransferase (ALT), LDH, and platelet count
Notes Results were reported in graphs for platelet count, ALT levels, LDH levels and urine output. Not in a form in which we can enter results into RevMan
ALT was listed as being measured along with AST but results for ALT were not reported in the results
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Not stated (risk of bias assessment from translation notes).
Allocation concealment? Unclear “sealed envelopes were distributed randomly to patients” (translation notes)
Blinding?
All outcomes
Unclear Not clear whether blinding or partial blinding was attempted
Incomplete outcome data addressed?
All outcomes
Yes No attrition or withdrawals reported.
Free of other bias? Yes No baseline imbalance apparent.
Overall risk of bias? Unclear Risk of bias assessment from translation notes. Possible selection bias (randomization methods not clear). Possible performance bias (there is no mention of blinding or use of a placebo)