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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007938. doi: 10.1002/14651858.CD007938.pub2
Methods Randomised, double-blind, placebo-controlled, cross-over, not enriched. No imputation method mentioned
Titration to maximum tolerated dose or 2400 mg daily over 1 week, then stable dose for 5 weeks (6 weeks total); 1-week washout, then cross-over
Participants Established phantom limb pain ≥ 6 months, N = 19, mean age 56 years, 21% women. PI before treatment > 3/10, initial pain score 6.4/10
14 completed both treatment periods
Interventions Gabapentin 2400 mg daily (max)
Placebo
Paracetamol + codeine 500 mg/30mg (max 12 tablets daily) allowed as rescue medication. Stable, low doses of TCAs continued
Outcomes No dichotomous efficacy data
Adverse events
Notes Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Unclear Not described - but probably OK - remote
Blinding?
All outcomes
Yes “identical, coded medication bottles containing identical tablets of gabapentin or placebo”
Incomplete outcome data addressed?
Efficacy
Unclear No imputation mentioned
Size
Efficacy
No 19 randomised
Study duration
Efficacy
Unclear 6 weeks each period
Outcomes reported No No dichotomous data