Methods | Randomised, double-blind, placebo-controlled, cross-over, not enriched. No imputation method mentioned Titration to maximum tolerated dose or 2400 mg daily over 1 week, then stable dose for 5 weeks (6 weeks total); 1-week washout, then cross-over |
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Participants | Established phantom limb pain ≥ 6 months, N = 19, mean age 56 years, 21% women. PI before treatment > 3/10, initial pain score 6.4/10 14 completed both treatment periods |
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Interventions | Gabapentin 2400 mg daily (max) Placebo Paracetamol + codeine 500 mg/30mg (max 12 tablets daily) allowed as rescue medication. Stable, low doses of TCAs continued |
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Outcomes | No dichotomous efficacy data Adverse events |
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Notes | Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5 | |
Risk of bias | ||
Item | Authors’ judgement | Description |
Allocation concealment? | Unclear | Not described - but probably OK - remote |
Blinding? All outcomes |
Yes | “identical, coded medication bottles containing identical tablets of gabapentin or placebo” |
Incomplete outcome data addressed? Efficacy |
Unclear | No imputation mentioned |
Size Efficacy |
No | 19 randomised |
Study duration Efficacy |
Unclear | 6 weeks each period |
Outcomes reported | No | No dichotomous data |