| Methods | Randomised, double-blind, placebo-controlled, parallel-group, partial enrichment. No imputation method mentioned Titration to pain ≤ 3/10 or limit of tolerability, or maximum 1800 mg daily (10 days in total) |
|
| Participants | Neuropathic cancer pain despite regular systemic opioid therapy. N = 121, mean age 60 years, 56% women. Pain at randomisation ≥ 5/10, initial pain intensity 7.3/10 | |
| Interventions | Gabapentin 1800 mg daily (max), n = 80 Placebo, n = 41 Any previous analgesics continued unchanged. One additional dose of opioid allowed for rescue medication |
|
| Outcomes | No dichotomous efficacy data Adverse events Withdrawals |
|
| Notes | Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5 | |
| Risk of bias | ||
| Item | Authors’ judgement | Description |
| Allocation concealment? | Yes | Remote pharmacy department provided numbered containers |
| Blinding? All outcomes |
Yes | “identical capsules” |
| Incomplete outcome data addressed? Efficacy |
Unclear | Imputation not mentioned |
| Size Efficacy |
Unclear | 121 randomised |
| Study duration Efficacy |
No | 10 days |
| Outcomes reported | No | No dichotomous outcomes |