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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007938. doi: 10.1002/14651858.CD007938.pub2
Methods Randomised, double-blind, placebo-controlled, parallel-group, partial enrichment. No imputation method mentioned
Titration to pain ≤ 3/10 or limit of tolerability, or maximum 1800 mg daily (10 days in total)
Participants Neuropathic cancer pain despite regular systemic opioid therapy. N = 121, mean age 60 years, 56% women. Pain at randomisation ≥ 5/10, initial pain intensity 7.3/10
Interventions Gabapentin 1800 mg daily (max), n = 80
Placebo, n = 41
Any previous analgesics continued unchanged. One additional dose of opioid allowed for rescue medication
Outcomes No dichotomous efficacy data
Adverse events
Withdrawals
Notes Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Yes Remote pharmacy department provided numbered containers
Blinding?
All outcomes
Yes “identical capsules”
Incomplete outcome data addressed?
Efficacy
Unclear Imputation not mentioned
Size
Efficacy
Unclear 121 randomised
Study duration
Efficacy
No 10 days
Outcomes reported No No dichotomous outcomes