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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007938. doi: 10.1002/14651858.CD007938.pub2
Methods Multicentre, randomised, double-blind, placebo-controlled, cross-over, not enriched. No imputation method mentioned
Titration over 2 weeks from 300 mg to maximum pain reliefat a tolerable dose or 2400 mg daily, then stable dose for 3 weeks (5 weeks total); 3-week washout, then cross-over
Participants Peripheral nerve injury with pain ≥ 6 months. N = 120, mean age 49 years, 53% women.
PI at randomisation > 30/100, initial pain intensity 53/100
Efficacy analysis based on 98 who completed both treatment periods
Interventions Gabapentin 2400 mg daily (max)
Placebo
Mean daily dose of gabapentin 2243 ± 402 mg
Paracetamol ± codeine and dextropropoxyphene permitted as rescue medication
Analgesics and NSAIDs used by ~50% during study
Outcomes ≥ 50% pain relief (weekly mean pain score)
≥ 30% pain relief
Marked pain relief (5-point scale)
Marked or moderate pain relief (5-point scale)
Adverse events
Withdrawals
Notes Oxford Quality Score: R = 2, DB = 2, W = 1, Total = 5
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Yes Central, remote allocation, “sealed code envelope”
Blinding?
All outcomes
Yes “capsules that were identical in appearance”
Incomplete outcome data addressed?
Efficacy
Unclear Imputation not mentioned
Size
Efficacy
Unclear 120 randomised
Study duration
Efficacy
Unclear 5-week period
Outcomes reported Yes At least 50% reduction in pain