Skip to main content
. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007938. doi: 10.1002/14651858.CD007938.pub2
Methods Randomised, double-blind, placebo-controlled, cross-over, not enriched. No imputation method mentioned
Titration to limit of tolerability or maximum of 3600 mg over 4 weeks, then stable dose for remainder of 8-week period; 2-week washout then cross-over
Participants Complete traumatic SCI at lumbar or thoracic level. N = 20, mean age 36 years, 35% women. Pain duration before treatment ≥ 6 months, PI at randomisation > 4/10, initial average daily pain 9/10
Interventions Gabapentin 3600 mg daily (max)
Placebo
Mean max tolerated dose of gabapentin 2850 ± 751 mg
No concurrent analgesics allowed
Outcomes Pain reduction (mean data only)
Adverse events Withdrawals
Notes Oxford Quality Score: R = 1, DB = 2, W = 1, Total = 4
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Unclear Not reported
Blinding?
All outcomes
Yes “identically appearing capsules”
Incomplete outcome data addressed?
Efficacy
Unclear Imputation not mentioned
Size
Efficacy
No 20 randomised
Study duration
Efficacy
Yes 8-week period
Outcomes reported No No dichotomous data