| Methods | Randomised, double-blind, placebo-controlled, cross-over, not enriched. No imputation method mentioned Titration to limit of tolerability or maximum of 3600 mg over 4 weeks, then stable dose for remainder of 8-week period; 2-week washout then cross-over |
|
| Participants | Complete traumatic SCI at lumbar or thoracic level. N = 20, mean age 36 years, 35% women. Pain duration before treatment ≥ 6 months, PI at randomisation > 4/10, initial average daily pain 9/10 | |
| Interventions | Gabapentin 3600 mg daily (max) Placebo Mean max tolerated dose of gabapentin 2850 ± 751 mg No concurrent analgesics allowed |
|
| Outcomes | Pain reduction (mean data only) Adverse events Withdrawals |
|
| Notes | Oxford Quality Score: R = 1, DB = 2, W = 1, Total = 4 | |
| Risk of bias | ||
| Item | Authors’ judgement | Description |
| Allocation concealment? | Unclear | Not reported |
| Blinding? All outcomes |
Yes | “identically appearing capsules” |
| Incomplete outcome data addressed? Efficacy |
Unclear | Imputation not mentioned |
| Size Efficacy |
No | 20 randomised |
| Study duration Efficacy |
Yes | 8-week period |
| Outcomes reported | No | No dichotomous data |