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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Mar 16;(3):CD007938. doi: 10.1002/14651858.CD007938.pub2
Methods Randomised, double-blind, placebo-controlled, parallel-group, not obviously enriched.
No imputation method mentioned
Dose adjusted on clinic successive visits, “based on clinical symptoms”, to a maximum of 1200 mg daily (12 weeks total)
Participants Painful diabetic neuropathy. N = 32, mean age 54 years, 53% female. Failed conventional treatment. PI ≥ 60/100 at randomisation
Interventions Gabapentin 1200 mg daily (max), n = 17
Placebo, n = 15
All participants continued with non-opioid analgesia
Outcomes ≥ 50% pain reduction
Notes Oxford Quality Score: R = 1, DB = 1, W = 0, Total = 2
Published as letter, some details confirmed by correspondence
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Unclear Not reported
Blinding?
All outcomes
Unclear Not reported
Incomplete outcome data addressed?
Efficacy
Unclear Imputation not mentioned
Size
Efficacy
No 32 randomised
Study duration
Efficacy
Yes 12-week period
Outcomes reported Yes At least 50% reduction in pain