Table 4.
Mouse lines for targeting Oligodendroglia
| Line | Construct | Cell Type | References |
|---|---|---|---|
| Cx47-EGFP | Knock-in | Mature Oligodendrocytes | *(Odermatt et al., 2003) |
| CNP-lacZ | Mouse 4.0 kb | OPCs and myelinating OLs | *(Gravel et al., 1998) *(Chandross et al., 1999) |
| CNP-lacZ neo | |||
| CNP-EGFP | Mouse 4.0 kb | OPCs, myelinating OLs, Multipotent SVZ cells, Schwann cells, and neuronal precursors | *(Yuan et al., 2002) (Belachew et al., 2003) (Aguirre and Gallo, 2004; Belachew et al., 2001) |
| CNP-Cre | Knock-in | OPCs, myelinating OLs, PNS Neurons, and Schwann Cell Precursors | *(Lappe-Seifke et al., 2003) (Genoud et al., 2002) |
| MBP-lacZ | Mouse 1.3 kb Mouse 1.34 kb Mouse 1.9 kb Mouse 3.1 kb Mouse 9 kb |
Mature Oligodendrocytes; Schwann cells (in 9 kb) | *(Turnley et al., 1991) *(Asipu et al., 2001) *(Gow et al., 1992) *(Foran and Peterson, 1992) |
| MBP-lacZ | Mouse 1.34–1.9 kb Mouse 6 kb |
Mature oligodendrocytes, non- neural epithelial cells, astrocytic shaped oligodendrocytes, compact perivascular oligodendrocyte lineage cells; Schwann cells (in 6 kb) |
*(Asipu et al., 2001) (Schiff et al., 2002) *(Forghani et al., 2001) |
| MBP-Cre | Mouse 1.3 kb Mouse 5.0 kb |
Mature Oligodendrocytes | *(Niwa-Kawakita et al., 2000) *(Hisahara S et al., 2000) |
| MBP-CreERT2 | Mouse 1.9 kb | Mature Myelinating Oligodendrocytes | *(Gow, 2011) |
| MOBP-EGFP | BAC | Mature oligodendrocytes | * GENSAT, 2008 |
| Prism 2.0: Snap25-DsRedMax/MOBP-YFP/Aldh1L1-Cerulean |
BAC | Neurons, Oligodendrocytes, and Astrocytes | *(Dougherty et al., 2012) |
| MOG-iCre | Knock-in | Mature Oligodendrocytes | *(Hovelmeyer et al., 2005) |
| PLP-lacZ | Mouse 2.4 kb –exon 2 | OPCs, myelinating OLs, and Schwann Cells | *(Wight et al., 1993) |
| PLP-sh ble-lacZ | Mouse 2.4 kb –exon 2 | OPCs, myelinating OLs, and Schwann Cells | *(Spassky et al., 1998) |
| PLP-sh ble EGFP | Mouse 2.4 kb –exon 2 | OPCs, myelinating OLs, and Schwann Cells | *(Sobottka et al., 2011) |
| PLP-EGFP | Mouse 2.4 kb –exon 2 | OPCs, myelinating OLs, and Schwann Cells; OLs, spinal cord stem cells, neuronal progenitors, and non-myelinating satellite cells in sympathetic glia |
*(Mallon et al., 2002) (Harlow et al., 2014) |
| PLP-GFP- S65T | Mouse 2.4 kb-intron 1 | OPCs, myelinating OLs, and Schwann Cells | *(Fuss et al., 2000b) |
| PLP-dsRed | Mouse 2.4 kb-intron 1 | OPCs, myelinating OLs, and Schwann Cells | *(Hirrlinger et al., 2005) |
| PLP-mtTA | Mouse 2.4 kb-intron 1 | Myelinating OLs, Bergmann glia, Schwann cells in adult sciatic nerve | *(Inamura et al., 2012) |
| PLP-Cre | Mouse 3.7 kb Mouse 2.4 kb |
OPCs, myelinating OLs, and Schwann Cells Embryonic Progenitors (neuroblasts and glioblasts) neuroepithelial and radial glial cells | *(Delaunay et al., 2008) *(Michalski et al., 2011) (Delaunay et al., 2009) |
| PLP-Cre ERT | Mouse 2.4 kb | OPCs, myelinating OLs, Schwann Cells, Bergmann glia; Neurons and immature astrocytes in ventral forebrain, dorsal cerebral cortex, and hippocampus | *(Doerflinger et al., 2003) (Guo et al., 2009) (Chung et al., 2013) (Guo et al., 2010) |
| PLP-Cre ERT2 | Mouse 2.4 kb | OPCs, myelinating OLs and Schwann Cells | *(Leone et al., 2003) |
| Ascl1/Mash1-Cre ERTM | BAC | OPCs, and Embryonic neuronal and oligodendrocyte-restricted precursors | *(Battiste et al., 2007) |
| Ascl1/Mash1-Cre ERT2 | Knock-in | OPCs, adult neural precursors; Hippocampal and olfactory bulb stem and progenitor cells | *(Kim et al., 2011) |
| NG2-dsRed | BAC | OPCs, pericytes, and microglia | *(Ziskin et al., 2007) *(Zhu et al., 2008) (Hall et al., 2014) |
| NG2-EYFP | Knock-in | OPCs, astrocytes | *(Karram et al., 2008) |
| NG2-Cre | BAC | OPCs, Astrocytes; neurons | *(Zhu et al., 2008) (Nishiyama et al., 2014) |
| NG2-Cre ERTM | BAC | OPCs, pericytes, astrocytes | *(Zhu et al., 2011) |
| NG2-CreER T2 | Knock-in | OPCs, gray matter astrocytes, and neurons | *(Huang et al., 2014) |
| Olig1-lacZ | Knock-in | OPCs | *(Zhou and Anderson, 2002) |
| Olig1-Cre | Knock-in | Motoneurons and OPCs | *(Lu et al., 2002) |
| Olig2-GFP | Knock-in | OPCs | *(Zhou and Anderson, 2002) |
| Olig2-Cre ERTM | Knock-in | Motoneuron, OPCs and astrocytes | *(Takebayashi et al., 2002) (Dimou et al., 2008) |
| Olig2-tva-Cre | Knock-in | OPCs | *(Schuller et al., 2008) |
| PDGFRα-GFP | Knock-in | OPCs | *(Hamilton et al., 2003) |
| PDGFRα-CreER T2 | PAC | OPCs, neurons, and astrocytes | *(Rivers et al., 2008) (Tripathi et al., 2010) |
| PDGFRα–CreERTM | BAC | OPCs and some ventral neurons | *(Kang et al., 2010) |
| Sox10-Venus | BAC | OPCs, Schwann cells, and neural crest cells | *(Shibata et al., 2010) |
| Sox10-Cre | PAC | OPCs, Oligodendrocytes, Neural Crest Cells, Enteric Glia | *(Matsuoka et al., 2005) (Laranjeira et al., 2011; Potzner et al., 2007; Stolt et al., 2006) |
| Sox10-fos-Cre (S4F:Cre) | Transgenic | OPCs, myelinating OLs, and neural crest cells | *(Stine et al., 2009) |
| Sox10-rtTA | Knock-in | OPCs, myelinating OLs, and neural crest cells | *(Ludwig et al., 2004) (Kanaykina et al., 2010; Wahlbuhl et al., 2012) |
| Sox10-iCreER T2 | BAC | OPCs, myelinating OLs, neural crest cells, and ependymal NG2 cells | *(Simon et al., 2012) (Ortega et al., 2013) |
Note:
*
denotes originator of the line. OPCs, oligodendrocyte progenitor cells; OLs, oligodendrocytes. mtTA, mammalian-optimized tetracycline-controlled transcriptional activator. Findings in some cells are the result of fate-mapping analyses.