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. Author manuscript; available in PMC: 2014 Sep 22.
Published in final edited form as: Curr Pharm Des. 2013;19(4):734–744.

Figure 1.

Figure 1

HDAC Inhibitors have great potential as anti-cancer agents, but their exact mechanisms of action are not completely established. Acetylation of histone induces gene expression by altering chromatin activity; acetylation of non-histone proteins affects a variety of physiological pathways including cell growth, chromatin remodeling, DNA replication and repair, cytoskeletal reorganization, autophagy, angiogenesis, and protein chaperone activity.