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. 2014 Sep 22;9(9):e107193. doi: 10.1371/journal.pone.0107193

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© 2014 Eng, Ruggeri

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Patient heterogeneity implies four prognosis clusterse driven by different LRPs. (B) Each of these clusters has a distinct prognosis. (C) Over time, there are significant changes in the prognostic association and specific LRPs at about 9 and 27 months, close to the second treatment times for platinum resistant and sensitive patients.