Table 1. Clinical differences between discovery and validation studies.
Studies | |||||
Discovery | Validation | ||||
TCGA | Tothill | Yoshihara | |||
N | 503 | 240 | 260 | ||
Age | Mean | 59.8 | 60.2 | NA | |
Stage | I, II | 24 | 9 | 0 | |
III, IV | 463 | 215 | 260 | * | |
Grade | 1 | 4 | 5 | 0 | |
2,3 | 473 | 218 | 260 | ** | |
Cytoreduction | Optimal | 102 | 53 | 103 | |
Suboptimal | 348 | 140 | 157 | + | |
Follow Up | |||||
OS | Median | 30 | 28 | 41.5 | |
PFS | Median | 13.2 | 14 | 19 |
*excludes Yoshihara data, p-value = .001597 when including Yoshihara data.
definition of optimal/suboptimal not clearly defined in Yoshihara data.