Table 2. Clinical associations for signaling clusters.
| Signaling Cluster | ||||||
| Plot Color | Black | Blue | Green | Red | ||
| n | 101 | 186 | 106 | 110 | ||
| Events | 100 | 95 | 93 | 73 | ||
| PFS Model fit | LRT | 0.281 | 0.001* | 0.001* | 0.001* | |
| R2 | 0.196 | 0.254 | 0.620 | 0.675 | ||
| Stage | % III/IV | 93% | 94% | 91% | 91% | p = 0.665 |
| Grade | % 3/4 | 86% | 85% | 80% | 88% | p = 0.420 |
| Clinical | Complete Response | 56 | 106 | 62 | 64 | |
| Response | Partial Response | 13 | 17 | 17 | 12 | |
| Stable Disease | 2 | 12 | 7 | 5 | ||
| Progressive Disease | 14 | 8 | 6 | 8 | ||
| Objective Response Rate | 68% | 66% | 75% | 69% | p = 0.522 | |
| Disease Control Rate | 70% | 73% | 81% | 74% | p = 0.292 | |
| OS | Median Months | 38.3 | 41.0 | 44.8 | 51.9 | p = 0.0875 |
| PFS | Median Months | 13.9 | 16.6 | 17.3 | 25.1 | p<0.001 |
| Notable Effects | VEGF | VEGF | Immune | VEGF | ||
| PDGF | PDGF | PDGF | ||||
| Ephrins | FGF | FGF | ||||
| Notch | TGFβ | Notch | ||||
*: p-value smaller than 0.001.
OS: Overall survival.
PFS: Progression-free survival.
LRT: Likelihood-ratio test.