1.6. Analysis.
Comparison 1 Fluvoxamine versus TCAs, Outcome 6 Depression scale ‐ Endpoint score: low=good (early phase) ‐ missing SDs or skewed data.
| Depression scale ‐ Endpoint score: low=good (early phase) ‐ missing SDs or skewed data | ||||||||
|---|---|---|---|---|---|---|---|---|
| Study | Depression scale | Fluvoxamine; mean | SD | n | comparator; mean | SD | n | Note |
| vs Imipramine | ||||||||
| Amore 1989 | HRSD‐21 | 22.6 | missing | 15 | 25.4 | missing | 11 | |
| Asakura 2005 | HRSD‐17 | 10.7 | 7.0 | 149 | 10.6 | 7.1 | 149 | skewed. |
| Cassano 1986 | HRSD‐17 | 13.4 | missing | 120 | 13.7 | missing | 119 | |
| Claghorn 1996 | HRSD‐21 | 21.1 | missing | 44 | 21.3 | missing | 44 | |
| Fabre 1996 | HRSD‐21 | 19 | missing | 46 | 18.3 | missing | 48 | |
| Feighner 1989 | HRSD‐17 | 12.5 | missing | 21 | 16.6 | missing | 27 | |
| Guy 1984 | HRSD‐17 | 14.2 | missing | 17 | 13 | missing | 16 | |
| Itil 1983 | HRSD‐16 | 12.7 | 8.2 | 9 | 10.4 | 6.8 | 14 | skewed. |
| Koetsier 2002 | HRSD‐17 | 19.4 | 9.7 | 27 | 15.5 | 8.0 | 25 | skewed. |
| Lydiard 1989 | HRSD‐17 | 18.6 | missing | 17 | 17.2 | missing | 18 | |
| March 1990 | HRSD‐17 | 15.9 | missing | 13 | 17.1 | missing | 15 | |
| vs Clomipramine | ||||||||
| Coleman 1982 | HRSD‐17 | 8.8 | missing | 41 | 8.6 | missing | 43 | |
| Ottevanger 1995 | HRSD‐17 | 15.1 | 8.1 | 20 | 13.9 | 7.4 | 20 | skewed. |
| vs Amitriptyline | ||||||||
| Harris 1991a | HRSD‐17 | 17.1 | missing | 29 | 10.0 | missing | 29 | |
| Murasaki 1998a | HRSD‐17 | 14.5 | 7.8 | 80 | 16.1 | 7.6 | 83 | skewed. |
| vs Nortriptyline | ||||||||
| Otsubo 2005 | HRSD‐17 | 13.5 | 7.7 | 32 | 15.7 | 6.5 | 29 | skewed. |