1. Imputation methods and borrowed SD use to obtain response rate.

			Early phase		Acute phase
Comparator		Study	Imputation methods	borrowed SD	Imputation methods	borrowed SD
TCAs	Imipramine	Cassano 1986	Yes	Yes	‐	‐
		Amore 1989	Yes	Yes	‐	‐
		Lydiard 1989	Yes	Yes	Yes	Yes
		Bramanti 1988	Yes	No	‐	‐
		Claghorn 1996	Yes	Yes	Yes	Yes
		Fabre 1992	Yes	Yes	No	Yes
		Feighner 1989	Yes	Yes	Yes	Yes
		Guy 1984	Yes	Yes	Yes	Yes
		Itil 1983	Yes	No	‐	‐
		Koetsier 2002	Yes	No	‐	‐
		March 1990	Yes	Yes	Yes	Yes
		Miller 2001	‐	‐	‐	‐
	Clomipramine	Coleman 1982	Yes	Yes	‐	‐
		de Wilde 1983	Yes	Yes	Yes	Yes
		Dick 1983	No	No	‐	‐
		Ottevanger 1995	Yes	No	‐	‐
		Zohar 2003	Yes	Yes	No	Yes
	Amitriptyline	B‐Schaapveld 1995	No	No	No	No
		Harris 1991	Yes	Yes	Yes	Yes
		Remick 1994	Yes	No	Yes	No
		Kostiukova 2003	No	Yes	No	Yes
		Murasaki 1998	No	No	‐	‐
	Nortriptyline	Otsubo 2005	Yes	No	No	No
	Dothiepin	Mullin 1988	Yes	Yes	Yes	Yes
		Rahman 1991	Yes	Yes	Yes	Yes
	Desipramine	Nathan 1990	Yes	No	‐	‐
		Tourigny Rivard 1996	‐	‐	Yes	Yes
Heterocyclics	Amineptine	Brunner 1994	Yes	No	‐	‐
	Mianserin	Moon 1991	No	No	No	No
		Perez 1990	Yes	Yes	Yes	Yes
	Maprotoline	Kasper 1989	Yes	No	‐	‐
		Mendonca Lima 1997	Yes	Yes	‐	‐
SSRIs	Paroxetine	Annseaau 1993	No	No	No	No
		Kato 2006	No	Yes	No	Yes
		Kiev 1997	Yes	Yes	Yes	No
	Sertraline	Nemeroff 1995	Yes	Yes	Yes	No
		Rossini 2002	Yes	No	Yes	No
	Fluoxetine	Dalery 1998	No	Yes	No	Yes
		Rapaport 1995	Yes	Yes	Yes	Yes
	Citalopram	Haffmans 1996	Yes	Yes	No	Yes
SNRI	Milnacipran	Clerc 2001	No	No	No	No
		Ansseau 1991b	No	No	‐	‐
		Ansseau 1991a	No	No	‐	‐
	Venlafaxine	Hackett 1998a	Yes	No	Yes	No
		Hackett 1998b	Yes	No	Yes	No
Newer ADs	Mirtazapine	Schoemaker 2002	No	Yes	No	Yes
	Moclobemide	Barrelet 1991	Yes	No	‐	‐
		Bocksberger 1992	Yes	No	‐	‐
		Bougerol 1992	Yes	No	‐	‐
Other conventional	Sulpiride	Ueda 2002	Yes	No	‐	‐