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. 2010 Mar 17;2010(3):CD006114. doi: 10.1002/14651858.CD006114.pub2

Comparison 7. Side effect profile: Fluvoxamine vs TCAs.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Cardiovascular ‐ Hypertension / tachycardia 4 363 Odds Ratio (M‐H, Random, 95% CI) 1.56 [0.51, 4.78]
1.1 vs Imipramine 1 36 Odds Ratio (M‐H, Random, 95% CI) 1.64 [0.31, 8.68]
1.2 vs Clomipramine 1 32 Odds Ratio (M‐H, Random, 95% CI) 5.0 [0.22, 112.88]
1.3 vs Amitriptyline 2 295 Odds Ratio (M‐H, Random, 95% CI) 1.04 [0.19, 5.81]
2 Cardiovascular ‐ Hypotension / bradycardia 8 930 Odds Ratio (M‐H, Random, 95% CI) 0.40 [0.21, 0.79]
2.1 vs Imipramine 4 560 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.10, 0.62]
2.2 vs Clomipramine 2 75 Odds Ratio (M‐H, Random, 95% CI) 1.23 [0.38, 4.02]
2.3 vs Amitriptyline 2 295 Odds Ratio (M‐H, Random, 95% CI) 0.20 [0.03, 1.18]
3 Dermatological ‐ Dermatitis / rash 3 348 Odds Ratio (M‐H, Random, 95% CI) 0.89 [0.17, 4.61]
3.1 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 0.54 [0.05, 5.99]
3.2 vs Desipramine 1 40 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.01, 8.26]
3.3 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 5.14 [0.24, 110.89]
4 Dermatological ‐ Sweating 11 1248 Odds Ratio (M‐H, Random, 95% CI) 0.49 [0.28, 0.88]
4.1 vs Imipramine 7 972 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.16, 0.66]
4.2 vs Clomipramine 3 216 Odds Ratio (M‐H, Random, 95% CI) 0.88 [0.45, 1.73]
4.3 vs Amitriptyline 1 60 Odds Ratio (M‐H, Random, 95% CI) 2.07 [0.18, 24.15]
5 Gastrointestinal ‐ Increased salivation 1 30 Odds Ratio (M‐H, Random, 95% CI) 9.33 [0.96, 90.94]
5.1 vs Imipramine 1 30 Odds Ratio (M‐H, Random, 95% CI) 9.33 [0.96, 90.94]
6 Gastrointestinal ‐ Dry mouth 17 1736 Odds Ratio (M‐H, Random, 95% CI) 0.27 [0.19, 0.38]
6.1 vs Imipramine 9 1055 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.16, 0.34]
6.2 vs Clomipramine 3 216 Odds Ratio (M‐H, Random, 95% CI) 0.43 [0.22, 0.81]
6.3 vs Amitriptyline 3 318 Odds Ratio (M‐H, Random, 95% CI) 0.11 [0.01, 1.06]
6.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.42 [0.16, 1.06]
6.5 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.08 [0.01, 0.70]
7 Gastrointestinal ‐ Oral discomfort / taste disturbance 2 308 Odds Ratio (M‐H, Random, 95% CI) 0.43 [0.06, 2.98]
7.1 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 0.36 [0.01, 8.85]
7.2 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.47 [0.04, 5.45]
8 Gastrointestinal ‐ Vomiting / nausea 18 1805 Odds Ratio (M‐H, Random, 95% CI) 2.35 [1.80, 3.07]
8.1 vs Imipramine 9 1055 Odds Ratio (M‐H, Random, 95% CI) 2.23 [1.59, 3.14]
8.2 vs Clomipramine 3 216 Odds Ratio (M‐H, Random, 95% CI) 2.13 [1.06, 4.27]
8.3 vs Amitriptyline 4 387 Odds Ratio (M‐H, Random, 95% CI) 2.86 [1.31, 6.23]
8.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 3.01 [1.00, 9.11]
8.5 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 2.71 [0.90, 8.19]
9 Gastrointestinal ‐ Constipation 15 1666 Odds Ratio (M‐H, Random, 95% CI) 0.53 [0.35, 0.80]
9.1 vs Imipramine 8 1008 Odds Ratio (M‐H, Random, 95% CI) 0.50 [0.27, 0.93]
9.2 vs Clomipramine 3 216 Odds Ratio (M‐H, Random, 95% CI) 0.55 [0.27, 1.09]
9.3 vs Amitriptyline 2 295 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.01, 7.25]
9.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.64 [0.25, 1.60]
9.5 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.03, 3.08]
10 Gastrointestinal ‐ Diarrhoea 5 518 Odds Ratio (M‐H, Random, 95% CI) 2.98 [1.08, 8.20]
10.1 vs Imipramine 2 136 Odds Ratio (M‐H, Random, 95% CI) 6.38 [1.27, 32.04]
10.2 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 0.36 [0.01, 8.85]
10.3 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 1.82 [0.66, 5.00]
10.4 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 9.81 [0.51, 189.07]
11 Gastrointestinal ‐ Weight gain 4 425 Odds Ratio (M‐H, Random, 95% CI) 0.53 [0.25, 1.09]
11.1 vs Imipramine 1 30 Odds Ratio (M‐H, Random, 95% CI) 1.0 [0.23, 4.31]
11.2 vs Clomipramine 1 86 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.05, 1.22]
11.3 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 3.27 [0.13, 81.01]
11.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.16, 1.21]
12 Gastrointestinal ‐ Weight loss 4 226 Odds Ratio (M‐H, Random, 95% CI) 2.76 [1.20, 6.34]
12.1 vs Imipramine 2 66 Odds Ratio (M‐H, Random, 95% CI) 1.88 [0.53, 6.67]
12.2 vs Clomipramine 1 86 Odds Ratio (M‐H, Random, 95% CI) 7.76 [0.91, 66.05]
12.3 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 2.83 [0.79, 10.21]
13 Gastrointestinal ‐ Increased appetite 2 335 Odds Ratio (M‐H, Random, 95% CI) 0.77 [0.08, 7.04]
13.1 vs Imipramine 1 100 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.03, 3.18]
13.2 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 3.27 [0.13, 81.01]
14 Gastrointestinal ‐ Anorexia 6 1104 Odds Ratio (M‐H, Random, 95% CI) 1.17 [0.54, 2.53]
14.1 vs Imipramine 5 869 Odds Ratio (M‐H, Random, 95% CI) 1.12 [0.47, 2.68]
14.2 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 2.18 [0.19, 24.38]
15 Neuropsychiatric ‐ Blurred vision 5 500 Odds Ratio (M‐H, Random, 95% CI) 0.47 [0.23, 0.97]
15.1 vs Clomipramine 2 118 Odds Ratio (M‐H, Random, 95% CI) 0.38 [0.06, 2.30]
15.2 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 0.26 [0.03, 2.39]
15.3 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.21, 1.56]
15.4 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.47 [0.04, 5.45]
16 Neuropsychiatric ‐ Dizziness / vertigo / faintness 14 1592 Odds Ratio (M‐H, Random, 95% CI) 0.27 [0.19, 0.38]
16.1 vs Imipramine 9 1055 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.15, 0.38]
16.2 vs Clomipramine 1 86 Odds Ratio (M‐H, Random, 95% CI) 0.21 [0.05, 0.80]
16.3 vs Amitriptyline 2 304 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.11, 0.83]
16.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.22 [0.07, 0.70]
16.5 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.75 [0.18, 3.06]
17 Neuropsychiatric ‐ Fatigue / tiredness / asthenia 5 565 Odds Ratio (M‐H, Random, 95% CI) 0.95 [0.52, 1.73]
17.1 vs Imipramine 2 200 Odds Ratio (M‐H, Random, 95% CI) 1.06 [0.25, 4.56]
17.2 vs Clomipramine 2 130 Odds Ratio (M‐H, Random, 95% CI) 0.86 [0.40, 1.85]
17.3 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 1.64 [0.27, 9.98]
18 Neuropsychiatric ‐ Headache 16 1621 Odds Ratio (M‐H, Random, 95% CI) 1.09 [0.73, 1.62]
18.1 vs Imipramine 8 1008 Odds Ratio (M‐H, Random, 95% CI) 1.20 [0.71, 2.01]
18.2 vs Clomipramine 1 32 Odds Ratio (M‐H, Random, 95% CI) 1.5 [0.33, 6.83]
18.3 vs Amitriptyline 4 387 Odds Ratio (M‐H, Random, 95% CI) 0.27 [0.07, 1.11]
18.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 1.82 [0.66, 5.00]
18.5 vs Desipramine 1 47 Odds Ratio (M‐H, Random, 95% CI) 0.86 [0.26, 2.79]
18.6 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 1.5 [0.24, 9.55]
19 Neuropsychiatric ‐ Tremor 12 1247 Odds Ratio (M‐H, Random, 95% CI) 0.50 [0.33, 0.75]
19.1 vs Imipramine 6 663 Odds Ratio (M‐H, Random, 95% CI) 0.60 [0.32, 1.13]
19.2 vs Clomipramine 3 216 Odds Ratio (M‐H, Random, 95% CI) 0.45 [0.15, 1.37]
19.3 vs Amitriptyline 2 295 Odds Ratio (M‐H, Random, 95% CI) 0.40 [0.08, 1.88]
19.4 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.03, 3.08]
20 Neuropsychiatric ‐ Involuntary movement other than tremor 3 499 Odds Ratio (M‐H, Random, 95% CI) 1.06 [0.32, 3.47]
20.1 vs Imipramine 2 430 Odds Ratio (M‐H, Random, 95% CI) 1.28 [0.36, 4.58]
20.2 vs Amitriptyline 1 69 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.01, 7.99]
21 Neuropsychiatric ‐ Insomnia 9 1039 Odds Ratio (M‐H, Random, 95% CI) 1.26 [0.82, 1.92]
21.1 vs Imipramine 6 674 Odds Ratio (M‐H, Random, 95% CI) 1.44 [0.87, 2.39]
21.2 vs Clomipramine 2 130 Odds Ratio (M‐H, Random, 95% CI) 0.82 [0.37, 1.81]
21.3 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 5.49 [0.26, 115.67]
22 Neuropsychiatric ‐ Sleepiness / drowsiness 15 1585 Odds Ratio (M‐H, Random, 95% CI) 0.94 [0.66, 1.33]
22.1 vs Imipramine 8 1019 Odds Ratio (M‐H, Random, 95% CI) 1.08 [0.80, 1.46]
22.2 vs Clomipramine 1 32 Odds Ratio (M‐H, Random, 95% CI) 1.09 [0.25, 4.71]
22.3 vs Amitriptyline 4 387 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.05, 1.21]
22.4 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.22, 1.42]
22.5 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 1.55 [0.40, 6.02]
23 Neuropsychiatric ‐ Agitation / anxiety 8 984 Odds Ratio (M‐H, Random, 95% CI) 1.64 [0.94, 2.84]
23.1 vs Imipramine 5 644 Odds Ratio (M‐H, Random, 95% CI) 2.24 [1.01, 4.97]
23.2 vs Clomipramine 1 32 Odds Ratio (M‐H, Random, 95% CI) 1.87 [0.15, 22.94]
23.3 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 0.71 [0.19, 2.58]
23.4 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 1.25 [0.31, 5.08]
24 Neuropsychiatric ‐ Manic symptom 2 565 Odds Ratio (M‐H, Random, 95% CI) 0.86 [0.06, 11.58]
24.1 vs Imipramine 1 330 Odds Ratio (M‐H, Random, 95% CI) 0.23 [0.03, 2.11]
24.2 vs Amitriptyline 1 235 Odds Ratio (M‐H, Random, 95% CI) 3.3 [0.34, 32.19]
25 Neuropsychiatric ‐ Completed suicide 2 118 Odds Ratio (M‐H, Random, 95% CI) 2.87 [0.29, 28.65]
25.1 vs Clomipramine 2 118 Odds Ratio (M‐H, Random, 95% CI) 2.87 [0.29, 28.65]
26 Neuropsychiatric ‐ Suicide wishes / gestures / attempts 3 489 Odds Ratio (M‐H, Random, 95% CI) 0.65 [0.17, 2.48]
26.1 vs Imipramine 1 330 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.01, 7.80]
26.2 vs Clomipramine 1 86 Odds Ratio (M‐H, Random, 95% CI) 0.95 [0.18, 5.00]
26.3 vs Dothiepin 1 73 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.01, 8.00]
27 Genitourinary ‐ Problems urinating 6 818 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.23, 0.83]
27.1 vs Imipramine 2 409 Odds Ratio (M‐H, Random, 95% CI) 0.18 [0.04, 0.71]
27.2 vs Amitriptyline 2 295 Odds Ratio (M‐H, Random, 95% CI) 0.55 [0.10, 2.94]
27.3 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.51 [0.19, 1.38]
27.4 vs Desipramine 1 40 Odds Ratio (M‐H, Random, 95% CI) 0.32 [0.01, 8.26]
28 Genitourinary ‐ Sexual dysfunction 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.75 [0.29, 1.99]
28.1 vs Nortriptyline 1 74 Odds Ratio (M‐H, Random, 95% CI) 0.75 [0.29, 1.99]