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. 2010 Mar 17;2010(3):CD006114. doi: 10.1002/14651858.CD006114.pub2

Comparison 9. Side effect profile: Fluvoxamine vs other SSRIs.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Cardiovascular ‐ Hypertension / tachycardia 1 120 Odds Ratio (M‐H, Random, 95% CI) 2.67 [0.11, 66.85]
1.1 vs Paroxetine 1 120 Odds Ratio (M‐H, Random, 95% CI) 2.67 [0.11, 66.85]
2 Cardiovascular ‐ Hypotension / bradycardia 1 120 Odds Ratio (M‐H, Random, 95% CI) 4.66 [0.53, 41.16]
2.1 vs Paroxetine 1 120 Odds Ratio (M‐H, Random, 95% CI) 4.66 [0.53, 41.16]
3 Dermatological ‐ Dermatitis / rash 1 88 Odds Ratio (M‐H, Random, 95% CI) 0.23 [0.01, 4.92]
3.1 vs Sertraline 1 88 Odds Ratio (M‐H, Random, 95% CI) 0.23 [0.01, 4.92]
4 Dermatological ‐ Sweating 2 157 Odds Ratio (M‐H, Random, 95% CI) 0.34 [0.12, 0.96]
4.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.22 [0.05, 0.91]
4.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.13, 2.49]
5 Gastrointestinal ‐ Dry mouth 2 157 Odds Ratio (M‐H, Random, 95% CI) 1.13 [0.54, 2.38]
5.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 1.59 [0.53, 4.77]
5.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.86 [0.31, 2.33]
6 Gastrointestinal ‐ Vomiting / nausea 6 649 Odds Ratio (M‐H, Random, 95% CI) 0.79 [0.46, 1.36]
6.1 vs Paroxetine 2 180 Odds Ratio (M‐H, Random, 95% CI) 0.91 [0.46, 1.78]
6.2 vs Sertraline 2 185 Odds Ratio (M‐H, Random, 95% CI) 1.78 [0.73, 4.33]
6.3 vs Fluoxetine 2 284 Odds Ratio (M‐H, Random, 95% CI) 0.49 [0.21, 1.13]
7 Gastrointestinal ‐ Constipation 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.46 [0.08, 2.75]
7.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.46 [0.08, 2.75]
8 Gastrointestinal ‐ Diarrhoea 3 257 Odds Ratio (M‐H, Random, 95% CI) 0.43 [0.23, 0.82]
8.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.36 [0.10, 1.33]
8.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.20, 1.59]
8.3 vs Fluoxetine 1 100 Odds Ratio (M‐H, Random, 95% CI) 0.37 [0.13, 1.07]
9 Gastrointestinal ‐ Anorexia 2 281 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.17, 1.95]
9.1 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.62 [0.16, 2.36]
9.2 vs Fluoxetine 1 184 Odds Ratio (M‐H, Random, 95% CI) 0.34 [0.01, 8.56]
10 Neuropsychiatric ‐ Dizziness / vertigo / faintness 3 238 Odds Ratio (M‐H, Random, 95% CI) 0.72 [0.33, 1.60]
10.1 vs Paroxetine 2 141 Odds Ratio (M‐H, Random, 95% CI) 0.65 [0.22, 1.92]
10.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.82 [0.25, 2.64]
11 Neuropsychiatric ‐ Fatigue / tiredness / asthenia 2 157 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.19, 1.64]
11.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 0.72 [0.15, 3.54]
11.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.46 [0.11, 1.94]
12 Neuropsychiatric ‐ Headache 6 642 Odds Ratio (M‐H, Random, 95% CI) 0.88 [0.59, 1.31]
12.1 vs Paroxetine 3 261 Odds Ratio (M‐H, Random, 95% CI) 0.96 [0.37, 2.52]
12.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.79 [0.33, 1.92]
12.3 vs Fluoxetine 2 284 Odds Ratio (M‐H, Random, 95% CI) 0.90 [0.50, 1.60]
13 Neuropsychiatric ‐ Tremor 3 277 Odds Ratio (M‐H, Random, 95% CI) 0.58 [0.21, 1.63]
13.1 vs Paroxetine 2 180 Odds Ratio (M‐H, Random, 95% CI) 0.60 [0.14, 2.51]
13.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.56 [0.13, 2.49]
14 Neuropsychiatric ‐ Insomnia 3 257 Odds Ratio (M‐H, Random, 95% CI) 1.17 [0.68, 2.01]
14.1 vs Paroxetine 1 60 Odds Ratio (M‐H, Random, 95% CI) 1.71 [0.52, 5.62]
14.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.72 [0.30, 1.73]
14.3 vs Fluoxetine 1 100 Odds Ratio (M‐H, Random, 95% CI) 1.51 [0.64, 3.55]
15 Neuropsychiatric ‐ Sleepiness / drowsiness 3 277 Odds Ratio (M‐H, Random, 95% CI) 1.06 [0.32, 3.46]
15.1 vs Paroxetine 2 180 Odds Ratio (M‐H, Random, 95% CI) 0.45 [0.02, 9.92]
15.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 1.62 [0.60, 4.41]
16 Neuropsychiatric ‐ Agitation / anxiety 5 465 Odds Ratio (M‐H, Random, 95% CI) 0.73 [0.40, 1.35]
16.1 vs Paroxetine 2 180 Odds Ratio (M‐H, Random, 95% CI) 1.31 [0.13, 12.78]
16.2 vs Sertraline 2 185 Odds Ratio (M‐H, Random, 95% CI) 1.12 [0.45, 2.80]
16.3 vs Fluoxetine 1 100 Odds Ratio (M‐H, Random, 95% CI) 0.47 [0.21, 1.05]
17 Neuropsychiatric ‐ Manic symptom 1 120 Odds Ratio (M‐H, Random, 95% CI) 2.67 [0.11, 66.85]
17.1 vs Paroxetine 1 120 Odds Ratio (M‐H, Random, 95% CI) 2.67 [0.11, 66.85]
18 Neuropsychiatric ‐ Completed suicide 1 217 Odds Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 8.12]
18.1 vs Citalopram 1 217 Odds Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 8.12]
19 Neuropsychiatric ‐ Suicide wishes / gestures / attempts 4 621 Odds Ratio (M‐H, Random, 95% CI) 1.99 [0.39, 10.05]
19.1 vs Paroxetine 1 120 Odds Ratio (M‐H, Random, 95% CI) 2.67 [0.11, 66.85]
19.2 vs Fluoxetine 2 284 Odds Ratio (M‐H, Random, 95% CI) 0.74 [0.05, 10.05]
19.3 vs Citalopram 1 217 Odds Ratio (M‐H, Random, 95% CI) 9.26 [0.49, 174.04]
20 Genitourinary ‐ Sexual dysfunction 4 422 Odds Ratio (M‐H, Random, 95% CI) 0.55 [0.26, 1.14]
20.1 vs Paroxetine 2 141 Odds Ratio (M‐H, Random, 95% CI) 0.75 [0.29, 1.91]
20.2 vs Sertraline 1 97 Odds Ratio (M‐H, Random, 95% CI) 0.28 [0.07, 1.12]
20.3 vs Fluoxetine 1 184 Odds Ratio (M‐H, Random, 95% CI) 0.52 [0.05, 5.80]