Comparison 11. Side effect profile: Fluvoxamine vs newer ADs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cardiovascular ‐ Hypotension / bradycardia	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 vs Moclobemide	1	40	Odds Ratio (M‐H, Random, 95% CI)	3.15 [0.12, 82.16]
2 Dermatological ‐ Sweating	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 vs Moclobemide	2	170	Odds Ratio (M‐H, Random, 95% CI)	1.67 [0.41, 6.70]
3 Gastrointestinal ‐ Dry mouth	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.37, 1.37]
3.2 vs Moclobemide	2	191	Odds Ratio (M‐H, Random, 95% CI)	4.73 [1.14, 19.57]
4 Gastrointestinal ‐ Vomiting / nausea	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	3.43 [1.90, 6.19]
4.2 vs Moclobemide	2	170	Odds Ratio (M‐H, Random, 95% CI)	2.01 [1.03, 3.92]
5 Gastrointestinal ‐ Constipation	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.99 [0.47, 2.08]
6 Gastrointestinal ‐ Diarrhoea	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	1.06 [0.52, 2.15]
7 Gastrointestinal ‐ Weight gain	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
7.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.41 [0.17, 1.03]
8 Gastrointestinal ‐ Increased appetite	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
8.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.40 [0.14, 1.15]
9 Neuropsychiatric ‐ Blurred vision	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
9.1 vs Moclobemide	1	130	Odds Ratio (M‐H, Random, 95% CI)	0.70 [0.11, 4.33]
10 Neuropsychiatric ‐ Dizziness / vertigo / faintness	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
10.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.40, 1.44]
10.2 vs Moclobemide	2	101	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.04, 28.71]
11 Neuropsychiatric ‐ Fatigue / tiredness / asthenia	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
11.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	1.07 [0.50, 2.27]
11.2 vs Moclobemide	3	231	Odds Ratio (M‐H, Random, 95% CI)	1.25 [0.42, 3.67]
12 Neuropsychiatric ‐ Headache	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	1.19 [0.65, 2.19]
12.2 vs Moclobemide	3	231	Odds Ratio (M‐H, Random, 95% CI)	1.23 [0.23, 6.72]
13 Neuropsychiatric ‐ Tremor	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
13.1 vs Moclobemide	3	231	Odds Ratio (M‐H, Random, 95% CI)	2.64 [0.96, 7.27]
14 Neuropsychiatric ‐ Insomnia	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
14.1 vs Moclobemide	2	191	Odds Ratio (M‐H, Random, 95% CI)	0.60 [0.26, 1.35]
15 Neuropsychiatric ‐ Sleepiness / drowsiness	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
15.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.29, 0.76]
16 Neuropsychiatric ‐ Agitation / anxiety	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
16.1 vs Mirtazapine	1	412	Odds Ratio (M‐H, Random, 95% CI)	0.17 [0.05, 0.61]
16.2 vs Moclobemide	3	231	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.53, 2.39]
17 Neuropsychiatric ‐ Manic symptom	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
17.1 vs Moclobemide	2	101	Odds Ratio (M‐H, Random, 95% CI)	3.18 [0.32, 31.64]
18 Neuropsychiatric ‐ Completed suicide	1		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
18.1 vs Moclobemide	1	61	Odds Ratio (M‐H, Random, 95% CI)	3.20 [0.13, 81.78]