Table 2.
Body mass index (BMI) and risk of peptic ulcer
| BMI (kg/m2) | |||||||
|---|---|---|---|---|---|---|---|
| <21.0 | 21.0–22.9 | 23.0–24.9 | 25.0–26.9 | 27.0–29.9 | ≥30.0 | Ptrend | |
| All Peptic Ulcer | |||||||
| Person-Years | 35,899 | 120,697 | 232,397 | 236,655 | 194,637 | 106,938 | |
| Cases | 23 | 74 | 125 | 151 | 143 | 75 | |
| Age-Adjusted HR (95% CI) | 1.10 (0.70–1.73) | 1.13 (0.85–1.52) | 1.00 | 1.21 (0.95–1.54) | 1.46 (1.14–1.86) | 1.46 (1.09–1.96) | <0.01 |
| Multivariate HR (95% CI)* | 1.14 (0.73–1.79) | 1.15 (0.86–1.54) | 1.00 | 1.20 (0.94–1.53) | 1.43 (1.12–1.82) | 1.38 (1.03–1.86) | <0.01 |
| Gastric Ulcer | |||||||
| Cases | 8 | 33 | 53 | 66 | 68 | 44 | |
| Age-Adjusted HR (95% CI) | 0.91 (0.43–1.92) | 1.18 (0.76–1.83) | 1.00 | 1.20 (0.83–1.74) | 1.57 (1.09–2.26) | 1.96 (1.30–2.95) | <0.01 |
| Multivariate HR (95% CI)* | 0.96 (0.45–2.03) | 1.22 (0.79–1.90) | 1.00 | 1.19 (0.83–1.72) | 1.52 (1.05–2.19) | 1.83 (1.20–2.78) | <0.01 |
| Duodenal Ulcer | |||||||
| Cases | 15 | 41 | 72 | 85 | 75 | 31 | |
| Age-Adjusted HR (95% CI) | 1.25 (0.71–2.20) | 1.10 (0.75–1.62) | 1.00 | 1.22 (0.89–1.68) | 1.37 (0.99–1.90) | 1.08 (0.70–1.65) | 0.17 |
| Multivariate HR (95% CI)* | 1.27 (0.72–2.24) | 1.11 (0.75–1.64) | 1.00 | 1.22 (0.89–1.67) | 1.36 (0.98–1.90) | 1.03 (0.67–1.59) | 0.24 |
*
Models adjusted for age (months), race (white, non-white), alcohol intake (0–4.9, 5–14.9, ≥15 g/day), periodontal disease (no, yes), physical activity (<3, 3–9, 9–18, 18–27, ≥27 MET-hours/week), smoking status (never, past, current), regular aspirin use (<2, ≥2 times/week), and regular NSAID use (<2, ≥2 times/week).