. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2014 Mar 26;12(10):1688–1694. doi: 10.1016/j.cgh.2014.03.021

Table 3.

Waist-to-hip ratio (WHR) and risk of peptic ulcer

	Baseline WHR^†
	<0.85	0.85–0.89	0.90–0.94	0.95–0.99	≥1.00	P_trend
All Peptic Ulcer
Person-Years	17,644	112,867	211,513	164,045	79,346
Cases	12	53	154	125	72
Age-Adjusted HR (95% CI)	1.58 (0.84–2.98)	1.00	1.42 (1.04–1.95)	1.40 (1.01–1.94)	1.57 (1.09–2.25)	0.03
Multivariate HR (95% CI)^*	1.59 (0.84–2.99)	1.00	1.39 (1.01–1.91)	1.33 (0.96–1.86)	1.46 (1.01–2.12)	0.08
Gastric Ulcer
Cases	6	20	68	61	36
Age-Adjusted HR (95% CI)	2.18 (0.86–5.49)	1.00	1.69 (1.02–2.80)	1.91 (1.14–3.21)	2.16 (1.23–3.79)	<0.01
Multivariate HR (95% CI)^*	2.22 (0.88–5.61)	1.00	1.62 (0.98–2.70)	1.78 (1.06–3.00)	1.88 (1.06–3.33)	0.04
Duodenal Ulcer
Cases	6	33	86	64	36
Age-Adjusted HR (95% CI)	1.24 (0.52–2.99)	1.00	1.26 (0.84–1.89)	1.10 (0.72–1.69)	1.22 (0.75–1.98)	0.60
Multivariate HR (95% CI)^*	1.21 (0.50–2.92)	1.00	1.26 (0.84–1.90)	1.09 (0.70–1.67)	1.19 (0.73–1.95)	0.68

Models adjusted for age (months), race (white, non-white), alcohol intake (0–4.9, 5–14.9, ≥15 g/day), periodontal disease (no, yes), physical activity (<3, 3–9, 9–18, 18–27, ≥27 MET-hours/week), smoking status (never, past, current), regular aspirin use (<2, ≥2 times/week), and regular NSAID use (<2, ≥2 times/week).

^†

WHR data collected in a supplemental 1987 questionnaire. Analysis based on follow-up from 1988–2010.