Table 4.

Physical activity^† and risk of peptic ulcer

	Physical Activity (MET-hours/week)
	<3.0	3.0–8.9	9.0–17.9	18.0–26.9	≥27.0	Ptrend
All Peptic Ulcer
Person-Years	65,359	132,200	185,081	155,866	388,718
Cases	52	90	126	98	225
Age-Adjusted HR (95% CI)	1.00	0.85 (0.60–1.20)	0.88 (0.63–1.23)	0.81 (0.57–1.14)	0.75 (0.55–1.03)	0.06
Multivariate HR (95% CI)*	1.00	0.83 (0.59–1.18)	0.86 (0.61–1.20)	0.80 (0.56–1.13)	0.75 (0.54–1.03)	0.08
Gastric Ulcer
Cases	18	46	61	48	99
Age-Adjusted HR (95% CI)	1.00	1.24 (0.71–2.15)	1.17 (0.68–2.01)	1.08 (0.62–1.89)	0.88 (0.52–1.48)	0.09
Multivariate HR (95% CI)*	1.00	1.21 (0.69–2.10)	1.12 (0.65–1.93)	1.05 (0.60–1.85)	0.88 (0.52–1.50)	0.13
Duodenal Ulcer
Cases	34	44	65	50	126
Age-Adjusted HR (95% CI)	1.00	0.64 (0.40–1.00)	0.72 (0.47–1.10)	0.66 (0.42–1.03)	0.69 (0.46–1.02)	0.32
Multivariate HR (95% CI)*	1.00	0.63 (0.40–1.00)	0.72 (0.47–1.10)	0.65 (0.41–1.02)	0.69 (0.46–1.03)	0.34

^†Physical activity based upon cumulative average of activity from all available questionnaires, prior to each two-year interval.

^*Models adjusted for age (months), body mass index (<21.0, 21.0–22.9, 23.0–24.9, 25.0–26.9, 27.0–29.9, ≥30.0 kg/m²), race (white, non-white), alcohol intake (0–4.9, 5–14.9, ≥15 g/day), periodontal disease (no, yes), smoking status (never, past, current), regular aspirin use (<2, ≥2 times/week), and regular NSAID use (<2, ≥2 times/week).