Table 3. Concentration response curve parameters for the inhibition of NO release and TNF-alpha release by rhamnetin.
|
|||
---|---|---|---|
Rhamnetin | IC50 (μM) | pIC50 | Hill slope |
NO release | 26.3 | 4.579 ± 0.03 | -3.0 ± 0.9 |
+ MLA (10μM) | 33.1 | 4.48 ± 0.10 | -1.6 ± 0.4 |
| |||
TNF-alpha release | 28.7 | 4.541 ± 0.06 | -3.5 ± 4.1 |
+ MLA (10μM) | 105.3 | 3.978 ± 0.41 | -1.0* |
best fit the sigmoidal dose response curve with no variable slope