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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurobiol Aging. 2014 May 27;35(11):2458–2464. doi: 10.1016/j.neurobiolaging.2014.05.016

Figure 1. Zileuton inhibits brain 5-lipoxygenase activity.

Figure 1

A. Levels of leukotriene B4 (LTB4) in brain homogenates of 15 months old wild type mice (WT), 3xTg mice treated with placebo (CTR) and 3xTg mice treated with zileuton (ZIL) (*p<0.05, ***p<0.001). B. Representative Western blot analyses of 5-lipoxygenase (5-LO) in brain homogenates of 15 months old wild type mice (WT), 3xTg mice placebo treated (CTR) and 3xTg mice zileuton treated (ZIL). C. Densitometric analyses of the immunoreactivities shown in the previous panel (*p<0.05). Results are mean ± sem.