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Schematic depiction of miR-22 function in cardiomyocytes. Several miR-22 targets (PurB, Sirt1, etc) and regulatory biological processes (Contraction and metabolism) are highlighted. Ac: acetyl groups; H: histone; HDAC4: histone deacetylase 4; MyoCD: myocardin; PGC-1〈: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PPAR〈: peroxisome proliferator activated receptor alpha; PurB: purine rich element binding protein B; Sirt1: sirtuin 1; SRF: serum response factor.
