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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Antiviral Res. 2014 Jul 19;110:10–19. doi: 10.1016/j.antiviral.2014.07.007

Figure 4. Effect of L-BHDU on 5-FU metabolism in vivo.

Figure 4

(A) The absolute concentration of 5-FU in plasma was measured by LC-MS/MS. Each point represents the average and standard deviation of 3 mice. (B) Representative MS chromatograms of individual mice show that BVdU interfered with 5-FU catabolism while L-BHDU did not. For each drug study, the intensity of each 5-FU assay run was normalized to the same signal intensity for the 30 and 60 min time points.