Table 3.
Maximum L-BHDU concentration two hours post final treatment
| Tissue | 150 mg/kg/day (n = 5) | 8 mg/kg/day (n = 4) | ||
|---|---|---|---|---|
| Max. Conc. | Ratio to Plasma | Max. Conc. | Ratio to Plasma | |
| Plasma | 13.9 (3.9)a | 1 | 0.3 (0.2) | 1 |
| Brain | 1.1 (0.3)b | 0.1 (0.03) | 0.1 (0.02) | 0.4 (0.3) |
| Skin (Human) | 11.3 (1.1)b | 0.9 (0.3) | 0.7 (0.1) | 3.1 (2.6) |
| Skin (Mouse) | 11.8 (1.0)b | 0.9 (0.2) | 0.7 (0.1) | 3.0 (2.5) |
| Heart | 13.7 (2.8)b | 1.0 (0.2) | 0.7 (0.1) | 2.9 (2.5) |
| Spleen | 18.8 (6.2)b | 1.4 (0.2) | 0.6 (0.2) | 2.1 (1.3) |
| Liver | 19.8 (4.1)b | 1.5 (0.3) | 1.4 (0.5) | 4.5 (1.1) |
| Kidney | 27.4 (3.5)b | 2.1 (0.4) | 1.3 (0.2) | 5.1 (3.1) |
| Lung | 30.4 (2.8)b | 2.3 (0.5) | 3.0 (0.8) | 11.2 (5.7) |
a
Mean (± Standard Deviation), μg/mL
b
Mean (± Standard Deviation), μg/g