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. Author manuscript; available in PMC: 2015 Nov 15.
Published in final edited form as: Biotechnol Adv. 2014 Aug 10;32(7):1256–1268. doi: 10.1016/j.biotechadv.2014.07.009

Fig. 1.

Fig. 1

Schematic illustration of a typical tumor microenvironment. Cancer cells reside in a complex microenvironment containing various supporting cells, extracellular matrix (ECM) and a suite of signaling molecules. These environmental components collectively contribute to the tumor-stromal interaction and tumor progression. Adapted from (Joyce and Pollard, 2009; Koontongkaew, 2013).